Tap ?

2022.01.19 01:55 neasjohnson Tap ?

Tap ? submitted by neasjohnson to WTFaucet [link] [comments]


2022.01.19 01:55 postmastern Иммунные клетки нюхают кровь: Почуяв каприловый альдегид в крови, макрофаги кровеносных сосудов заставляют их воспаляться.

Иммунные клетки нюхают кровь: Почуяв каприловый альдегид в крови, макрофаги кровеносных сосудов заставляют их воспаляться. Мы чувствуем запах с помощью обонятельных рецепторов в носу, которые по цепочке нейронов передают запаховую информацию в специальный отдел мозга. У иммунных клеток нет ни носа, ни мозга, и когда мы говорим, что они что-то чуют, то имеем в виду, что они реагируют на какое-то пахучее вещество. Вещество это — окатаналь, или каприловый альдегид. В высокой концентрации он обладает резким жирным запахом (иногда его сравнивают с несвежей подогретой курицей), но если октаналь разбавить, он начинает приятно пахнуть апельсином.
Макрофаг под электронным микроскопом. (Фото: NIAID / Flickr.com)
У каждого из нас в крови есть небольшие количества октаналя. Однако сотрудники Института иммунологии в Ла-Холья обнаружили, что у людей с повышенным уровнем «плохого» холестерина одновременно повышается и уровень октаналя. Напомним, что «плохим» холестерином называют липопротеины низкой плотности. Все липопротеины представляют собой сложные частицы из белков и липидов, которые нужны для транспорта этих самых липидов по организму, но свойства именно липопротеинов низкой плотности таковы, что они повышают риск сердечно-сосудистых и метаболических расстройств.
Те же исследователи несколько лет назад обнаружили, что у иммунных клеток макрофагов, обитающих в стенках артерий, есть обонятельные рецепторы — то есть белки, которые способны связываться с молекулами, которые мы называем пахучими. Есть у макрофагов рецептор и для октаналя — это белок OR6A2.
Макрофаги — блуждающие клетки, которые бродят по тканям и ищут, что не так. Они постоянно принимают различные сигналы от окружающих клеток и сами рассылают молекулярные послания. В частности, макрофаги запускают и поддерживают воспалительную реакцию, которая, как мы знаем, служит иммунным оружием против инфекций. Однако воспаление начинается не только из-за инфекций. Атеросклеротические отложения и другие изменения в сосудистых стенках сопровождаются воспалением, которое только ухудшает ситуацию. Скажем, макрофаги начинают генерировать воспалительные сигналы, почувствовав избыток «плохого» холестерина.
Ещё один фактор, который заставляет макрофагов простимулировать воспаление, это тот самый октаналь. Эксперименты с мышами показали, что если у макрофагов отключить ген рецептора к октаналю, воспаление в сосудах в принципе будет намного слабее, чем у обычных мышей, и вероятность атеросклеротических липидных отложений снизится. Того же самого эффекта можно добиться, если закрыть обонятельный рецептор макрофагов другой пахучей молекулой — цитралем: связавшись с цитралем, рецептор не сможет связаться с октаналем. Результаты экспериментов описаны в Science.
Почему у людей с повышенным «плохим» холестерином одновременно повышается уровень октаналя? Возможно, он приходит в организм вместе с едой (той же, что повышает уровень холестерина), возможно, он получается как побочный продукт каких-то процессов в клетке, которые сопутствуют биохимическим и физиологическим аномалиям. Так или иначе, если у человека уровень сосудистого воспаления так же сильно зависит от октаналя, можно было бы подумать о медицинских средствах, которые заставили бы наших макрофагов «зажать нос», ослабив тем самым развитие атеросклероза и других сердечно-сосудистых патологий.
Автор: Кирилл Стасевич
Источник
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2022.01.19 01:55 loofyg Bettas and bubblers

I have a female giant koi in a 32 gallon tank with 8 neon tetras, one harlequin and a nerite snail. I've heard bettas don't like massively agitated water movement, I was wondering if this goes for all betta fish or just the long-finned variety?
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2022.01.19 01:55 Vanmagnogen TF Tobacco Vanille Vs JPG Ultra Male

I live in Minnesota, I know both these fragrances are great for the cold weather but I can only afford to buy one. Which one do you think is better?
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2022.01.19 01:55 Shervinator1979 60 fps

anyone enabled 60 fps? It warns you that ur device will heat up.
Cheers.

p.s. I have pixel 6
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2022.01.19 01:55 EggplantFriendly4941 Advice On Starting A Cyber Security Career

Looking for some tips on how to get my foot in the door and start a career in Cyber Security. I have two related undergraduate degrees - one in Information Assurance, the other in Computer Science, which I just recently completed. I also have an active CompTIA Security+ certification. I've been applying non-stop since I graduated and still haven't been able to land an entry level job.
When I've reached out to recruiters and contacts in industry, I've received conflicting advice. One camp tells me that I'm struggling because of a lack of relevant job experience, and that I should focus my efforts on landing a help desk position to "put in my time" before applying for a cyber security job, even if the advertisement lists 0-2 years' experience. The other camp tells me that help desk and other general IT positions won't teach me any relevant skills, and that I'd be wasting my time when middle and senior level cyber security positions only care about the time you've spent in the cyber security industry specifically.
This has left me very conflicted as to how I should be approaching my first job. Should I be working from the ground up at help desk, even when the job requirements are far below my education level? Or should I continue to passionately apply to the cyber security positions I'm interested in, even if nobody seems interested in my candidacy?
Thanks so much for reading!
-Eggplant
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2022.01.19 01:55 FanNational Davoodi or Bruning for stats methods

What the title says, just which one is better.
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2022.01.19 01:55 StarryPagan98 I owe you all a apology

So i was ranting about Lilith and telling people what to believe especially to my fellow pagans who worship her
It's just that i just care about the future of paganism.
I mean it just takes one bad egg to ruin a reputation. And having somebody worshipping lilith in the pagan community and a influential christian person seeing this, can put us on the radar of "All pagans worship demons"
For example, you know that one Asatru guy who attacked the white house, because of this our reputation is now permanently scarred, and now we get the "All pagans are racist" Just because of bad person.
It's also because i've been taught historical paganism and who we should worship and what is historically correct.
And there's a invisible list, well metaphorical, it's there but not, and a section is called "Who you shouldn't worship and evil entities and entities that aren't historically correct" so things like medusa, the goddess Empusa, Fenrir, we don't worship
And guess who is on the list, Lilith, Mostly because she isn't historically correct as a goddess, and schemes all throughout christian jewish lore, and even in her sumerian days she's known as a evil air spirit.
And that is still engrained in me
But overall do think Lilith is a interesting character, although i actually don't believe in her, she's a cool entity "Who you shouldn't worship and evil entities and entities that aren't historically correct", that's badass, because lets face it, saying no to a powerful deity simply because you wanted to stay on a tree and be on top once in awhile as well as other things, i mean not many entities are storm air entities , is badass.
And I will be edgy, what is not badass looking about her, I mean she has a succubus form, she has a vampire form, a lot of forms, etc
But not the point, anyways, i am deeply sorry and owe you guys all a apology
submitted by StarryPagan98 to DemonolatryPractices [link] [comments]


2022.01.19 01:55 RTNoftheMackell What's the consensus on solid state hydrogen storage?

Is there one?
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2022.01.19 01:55 SpectyteCovelight La piel de los de Tlahuelilpan después de 3 años.

La piel de los de Tlahuelilpan después de 3 años. submitted by SpectyteCovelight to Mujico [link] [comments]


2022.01.19 01:55 Saultyrscommunity Why did maxing 6 runes cost 10m mana

I don’t understand the point of maxing runes costing so much. When I was a new player it took me weeks to upgrade runes because of the cost. Not that I can farm the higher level stuff I usually hit around 20m mana but rolling runes drains that pretty quick. I got lucky and pulled 2 new units that I was trying to get the best runes I could for it. So far as the title states it took me 10m mana for 6 runes that’s outrageous. That doesn’t even include the 1-2m mana I spend on runes that rolled junk. Can this be the next change for runes com2us. Make rune upgrades a set price please.
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2022.01.19 01:55 yeinpinkpolo [FRESH] yaphet - dirty east

[FRESH] yaphet - dirty east submitted by yeinpinkpolo to SoundCloudHipHop [link] [comments]


2022.01.19 01:55 a-stranded-rusalka Why a Ripperdoc rembered to fight.

Hello folks, I want to take a moment to... just maybe vent about a session I just had? Gush is probably the best way to put it.
I play Wiara Malutka, who moved to Night City from Poland as a qualified doctor to escape the rapid radicalisation of the Catholic Church (and considering where Poland stands today I can only imagine what that actually entails in Cyberpunk). At the start of the story, she has been working for the FFB (The Fern Flower Brigade, or lovingly called the Flower Boys thanks to the slavic embroidered flower patterns they wear on their jackets), a largely Polish gang in Little Europe that has made their success with several illegal garden plots and actual food sold to the public. Wiara is their ripperdoc, installing cyberware, patching up the boys and generally being useful. The general hook right now is that Continental Brands have moved in to Little Europe, and are working Night and Day to get rid of the FFB and their contraband, and the gangs of Little Europe trying to band together to stand up to the Kibble Queen.
Now... Wiara is a genuinely good person. She's by no means weak, but she has a soft heart. And as we Poles say, if you have a soft heart, you need a tough ass to go with. So far in the story she has been mainly interacting with the gangs. Some close calls with 6th Street, helping her fellow Flower Boys because they believe that they need to look out for one another. You know, we're all slavs, we need to care for each other (Us Poles are quite collectivist in that way, especially abroad). It has been a bit easy for her to believe in the kindness of the human heart, because the people she works with look out for their own.
Last session, near the beginning someone asked her why she didn't join Trauma Team. With a university education she could have had it all. Never worry about anything. And in that moment, having spent so long amongst more or less decent people... Wiara had to think "yeah... why didn't I join Trauma Team? Maybe I could do more good there?"
The session went on. We had to get past a homeless guy to get into a building for a Job. Wiara being the samaritan that she is, went over to have a chat. He was barely coherent, and was missing an arm. Puncture wounds in his neck. I thought... scavs? Can't be. The ones Wiara knows of would take the meat for food. My GM makes me roll, and informs me that if people get cyberware from a Corp, and then leave that job or are fired, they need to pay for the cyberware they get. If they cannot pay, its not uncommon for the Corp to send someone to drug them and 'seize' the cyberware. Like a fucking mortgage.
Wtf.jpeg
Me and the other player are sat there picking up our jaws. I say, well... seeing this guy so beaten up an broken down, could she install him a medical cyberarm at least? We make some rolls. From Wiara's current resources, she can't really get her hands on that kind of ware. She has the eddies, but not the supplier. Best bet would be to take him to a hospital and if she really wanted to, pay for him to get a medical grade cyberarm.
Well. Session derails as we take this poor bastard to her clinic, feed him, give him a haircut, something to drink, and then take him to the hospital. All this time, Wiara genuinely believes a hospital will help.
So we arrive at the hospital. The clerk gets some details. We are told to go sit down and wait. Someone will see us. So we go sit down and wait. The GM describes several people come and go, and asks intermittently if we want to just leave the poor homeless dude to it. Nope, we say. We stay and wait. At this point, in Wiara's head, she's remembering that yeah, bureaucracy takes a long ass time. Corpos come in and don't even have time to sit down. Finally, a doctor comes out and comes to us. Finally, Wiara thinks. The homeless guy has at this point become a bit more lucid. The doctor asks his name, age etc. So the guy is named Stanley Riggs. Sargent Stanley Riggs to be exact. The doctor takes the details and walks us over to cybernetics. He says 'sit down, I'll be right back to do the procedure and set you up in a room.' Awesome. Then... a different man walks out of the room the doc just went into. Uh oh. He is in a suit, he has a gold cyber arm. Double uh oh. He offers for Stanley to be taken into the office in a wheelchair. GM makes me roll a couple of checks. He tells me; you know that if he uses the wheelchair, he will have to pay for it. So I offer to help Stanley walk instead. Unnecessary charges avoided. We go into the office the doc went into. It has a plack on it that reads "Arlo Washington — Finances."
My heart drops. My co-player has this pained look in their eyes. Wiara has a moment of realisation. They're not going to help him.
Mr Washington proceeds to very politely explain that Sgt Riggs has defaulted on his payment for his cyber arm, and his account went into collections. That although his account is still technically overdrawn, since the cyberarm has been reclaimed, they will take his 'circumstances' into account and not pursue further payments just yet. He says that because of his financial unreliability, they cannot provide him with a new prosthesis without an approved bank loan from Night Corp. He suggests that Night Corp has a special programme for veterans and could lend him the money at a reasonable 50% interest, and that they could do it within the hour even, to cover the cost of the arm and the hospital stay and the installation fee (which by this fuckers maths would come to 1200 eddies. Even though.... a cyberarm costs 500). Or, that they can book him in for 6 years from now when his account clears. Wiara points out that she is actually willing to pay the money upfront, but is told as she is not related to Stanley they shouldn't even have let her into the room really, but it would appear he relies on her for communicating, so they made the compromise to let her sit in.
At this point, Wiara's heart is in her stomach. She remembers 100% why she didn't join TT. Why she works with a gang. This shot of corporate bullshit sobers her right up. Things are clear. The world is fucked. The doc keeps his gaze to the floor. And Wiara felt enraged. She and Stanley are walked out by the doctor, who still doesn't look at up, but says he's sorry no help could be provided today.
I remember wanting to snap at him in character, and ask how he can sleep at night turning away people in need. Knowing he breaks his Oath for a Corp that wouldn't give a shit about him. But. Wiara bites her lip and walks Stan back to the car and her team mate. We get ready to go after some angry crying on Wiara's part. A small side door opens.
Its the doc. He walks up to us and apologises again. Tells Wiara not to give up on the poor vet, and shakes her hand, sliding her a note that says "I can't in good conscience just ignore a fellow vet. If you still want to help, go visit the Holy Angels Church, and ask for Rick. Tell him Dr. Moore sent you."
And that... is how Wiara decided to take a job with the 6th Street Gang to Rob a Militech Convoy.
I loved this part of the session so much because it was a horribly sobering reminder for my character that the world is selfish and cruel, without killing her desire to heal and help. It gave us as a party a clear glimpse of why the people we work with are so opposed to corporations in the first place. Showing that there are people I the cogs who want change but are practically powerless. The GM did such a fantastic job as Mr Washington, so polite and smiling and soft spoken whilst basically telling my character and this NPC that there is no way in hell we can get what we came for. It was horrible, and slimy and just eugh. It makes me mad thinking about it. But the note from the Doctor as the end of that particular scene I think was honestly so on point. It was bitter with a tiny hint of sweet. Wiara will still heal people. She will take care of those who need it. But now she firmly believes that for that to happen, she needs to remember just how shit things are, and let it motivate her to make change.
Of course the militech job may very well kill her. And even if it doesn't I doubt she will make grand change. Its cyberpunk after all. But it was such a strong moment for her, I absolutely loved it, and am so grateful to my GM for the effort he put into this random encounter we ran into, and the grace with which he took the improv that was the whole ordeal.
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2022.01.19 01:55 Curious_Maintenance9 Infinite Drakes From The Start (exploit)

Introduction:
This was one of my favorite games in my childhood. Not just because it's an overall solid game to play, but because I had discovered and exploit on my own. I've never done this with a game before. I noticed very little mention of this exploit online or in this forum. I didn't look too hard, so forgive me if this has been discussed before. I recently started playing this game again just for the nostalgia. I'm playing the game of the year edition on my xbox one and it is exactly how I remember it. I understand this exploit might make people feel like the game is broken, but I can't resist. How can I not use it?
The premise:
When starting a game I go as an Imperial. I make personality and luck my primary attributes. I make sure I have speech craft and mercantile as my primary attributes. I then choose The Lady as my sign. I loot everything in the census office and give the wood elf his ring. At this point the merchant in Seyda Neen will have a 100 disposition towards me.
The exploit:
While stretching out the limits of barter, I am now able to sell items for more than I can buy them. I sell everything in my inventory from the census office for as much as I can. I then buy as much as I can from the merchant. I typically go for stackable items in which the merchant immediately replenishes the stock after purchase. I clean out the merchant in Seyda Neen and make my way to Balmora Fighter's guild and join. This makes it easier to get the disposition of merchant with 2,000 gold up to 100 in which I clean him out as well. From this point I have enough gold to bribe other merchants to have a disposition of 100. I then clean out all the gold available in Balmora by selling items for more than what I am buying. I train from all the trainers, especially the ones that barter because I can get the gold I used to train back from them. Once I've done enough training to power level (x5 for two attributes and 1 into luck), the gold from all of the merchants would have replenished because it would be a new day.
Rinse and Repeat:
Of course this is tricky at first, but only gets easier as I level up my mercantile and speech craft, and put points into personality. I keep doing this and without killing a single enemy, I have 100 in all of my attributes (besides luck), and can craft whatever potion I desire.
Epilogue:
I'm just getting back into the game and still need to re learn a few things (like enchanting), so I'm sure if I had more knowledge, I could take this exploit further. Where I am at with my current game, I'm just happy with my stats, my potions, and basic equipment available to me from the start to just go ahead and play out the game. I kill everything with relative ease, and the more complex fights, I have plenty of strong home made healing potions to keep me going. Again, this exploit breaks the game, so if you are playing in order to mold you're own specific character, then go ahead. The game is pretty easy overall without the exploit.
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2022.01.19 01:55 HistAnsweredBot Are there any stories of people who have gone from slave to slave master/owner?

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2022.01.19 01:55 Excellent-Pie003 What did this moment mean between the two, & the connection?

What did this moment mean between the two, & the connection? submitted by Excellent-Pie003 to GODZILLA [link] [comments]


2022.01.19 01:55 ExcellentFlounder873 Who wanna jerk to emely?

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2022.01.19 01:55 jobsinanywhere Covid cases surge 300% in California in a month

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2022.01.19 01:55 Immediate_Designer33 That dog is really smart

That dog is really smart submitted by Immediate_Designer33 to memes [link] [comments]


2022.01.19 01:55 ghfanforlife To know the truth about Michael Malone and Joker’s relationship, read Michael backwards and flip the third and fourth letters

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2022.01.19 01:55 beanssimulator Should a Class 466 (2 car Class 465) be added to Waterline?

View Poll
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2022.01.19 01:55 Sensitive-Yoghurt795 Funny

https://clips.twitch.tv/GenerousDarkWhalePartyTime-cSjiEXcihnZJvvsl
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2022.01.19 01:55 saddigilmore Coucou

Coucou submitted by saddigilmore to flexingsquirrels [link] [comments]


2022.01.19 01:55 SirSallas Chad Skitarii Marshal is ready for the local tournament on Friday!

Chad Skitarii Marshal is ready for the local tournament on Friday! submitted by SirSallas to AdeptusMechanicus [link] [comments]


2022.01.19 01:55 kidhater23 [UPDATE] car is making flapping noises when braking or at high speeds

my car is making a flapping sort of noise thats slow and heavy when braking and fast when at higher speeds (above 60) its a 2008 toyota yaris
update i got a friend to take a video of the sound here
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